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Front Endocrinol (Lausanne) (2013) 4:76
'cause there's a lot of money to be made here
Investment analysts expect production costs of orforglipron to be 30 to 50% lower than injectables
This direct entry means the compound avoids enzymatic degradation in the gut and first-pass metabolism in the liver, both of which destroy the vast majority of peptide-based medications when swallowed
doi: 10.1056/NEJMoa1812389 9 MosenzonOWiviottSDCahnARozenbergAYanuvIGoodrichELet al
