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Further research must be conducted on the additional potential benefits of DPP-4 inhibitors before the recommendation for DPP-4 inhibitors over SGLT2 inhibitors or GLP-1 agonists as a second-line agent for patients with type 2 diabetes can be strengthened

While robust synaptic effects have been demonstrated in animal models, consistent replication in humans remains limited, underscoring the need for translational research and validated biomarkers

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