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Injection dates and notes Keep injection-day notes in one place for personal organization

Knockout of SLC5A2, which encodes the protein of SGLT-2 in rodents, reportedly caused polyuria, hyperphagia, increased glucosuria, and decreased aldosterone, and increased circulation renin

Severe nausea, vomiting, or reduced oral intake may lead to dehydration or electrolyte imbalances that manifest as confusion or difficulty concentrating

Several pharmacological therapies used to treat nutritional obesity and metabolic dysfunction, or those that have targeted pathways disrupted due to pathogenic variants (eg, setmelanotide in POMC deficiency), have been trialed in patients with HO, with variable success limited to a small number of patients [54]

Any discrepancies were resolved through discussion to reach a consensus