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Your body makes GLP-1 in response to food, and the single most powerful lever is fiber: gut bacteria ferment it into compounds that trigger GLP-1 release, and the biggest gains build as you keep eating more of it

Specifically, increasing cellular cAMP levels by directly activating adenylyl cyclases with forskolin [17] and/or by inhibiting the breakdown of cAMP with phosphodiesterase inhibitors [17

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Activating these receptors essentially signals to your brain that it is processing energy, which can inadvertently increase alertness and delay sleep onset