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68,69 In addition to activating the cAMP/PKA pathway, activation of GLP-1R has been associated with other intracellular mechanisms such as the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, which plays a crucial role in regulating key functions like cell survival, mitochondrial activity, and autophagy, or the breakdown and recycling of damaged cellular components

It is a 30-amino acid peptide hormone that is produced in the intestinal epithelial endocrine L-cells

535 After FMT treatment, the proportion of proinflammatory Enterobacteriaceae decreased, the abundance of Collinsella increased, and the expression of IL-6 and IL-1 significantly decreased