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the administration of N-acetyl-GIP and N-pyroglutamyl-GIP resulted in an attenuation of hyperglycemia in ob/ob mice [125], and several other GIP analogues have been reported to improve glucose tolerance in both lean and obese mice [126-128]

The debate, therefore, extends beyond patents alone

Insulin resistance syndrome Indeed, environmental factors and genetic predispositions play significant roles in the development of insulin resistance syndrome, which is characterized by an increase in adipose tissue mass

The lighter body, improved insulin sensitivity, and reduced inflammation create an optimal foundation for physical performance

Current advanced therapies for moderate to severe IBDs such as biologic agents (anti-TNF, anti IL12/23, anti-IL-23, and anti-integrins) and small molecules (JAK inhibitors and anti-S1P) have improved the therapeutic armamentarium available to IBD physicians, however, their use is limited by adverse effects, high costs, and a ceiling of effectiveness