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GLP-1 medications are extremely powerful medications, so side effects and adverse events can occur when theyre prescribed to poorly selected patients without education, close monitoring, and support, says Saunders

Can I take laxatives while on GLP-1 therapy

In addition to common side effects such as nausea and diarrhea, these drugs can occasionally cause pancreatic inflammation and, in very rare cases, are linked to a rare form of thyroid cancer in people with a genetic predisposition

Tirzepatide binds the GLP-1 receptor with lower affinity than semaglutide and exhibits distinct signaling bias, which may result in comparatively different downstream GLP-1 receptor signaling dynamics 23

Gastrointestinal effects represent the most likely indirect pathway