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You should contact your GP or healthcare professional urgently if you experience any of the following: Persistent rapid heart rate (tachycardia) at rest, particularly if your resting heart rate exceeds 100 beats per minute consistently Palpitations accompanied by chest pain, shortness of breath, or dizziness , which could indicate a more serious cardiac condition Irregular heartbeat or sensation of skipped beats , especially if this is new or persistent Syncope (fainting) or pre-syncope (feeling like you might faint), which may suggest significant hypotension or cardiac arrhythmia Chest discomfort or pressure , particularly if associated with exertion, sweating, or radiation to the arm or jaw Seek immediate emergency care (call 999) if you experience severe chest pain, difficulty breathing, or symptoms suggestive of a heart attack or stroke

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In a human clinical trial, pasteurized Akkermansia supplementation was associated with improvements in insulin sensitivity and plasma lipid levels in overweight and obese participants

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Patients were randomly assigned to receive sitagliptin 100 mg daily or glipizide 5 mg daily