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Sutin et al., 2020)

Myocardial Metabolism The GLP-1 agonists increase myocardial glucose uptake and change the metabolic pathways toward glucose oxidation by increasing the energy efficiency of the heart during ischemia or failure [9]

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Other reported changes include increase of Lactobacillus and Butyrivibrio, together with restoration of Firmicutes/Bacteroidetes ratio [293]

In clinical trials for type 2 diabetes (SURPASS), nausea was reported by approximately 12-29% of patients receiving tirzepatide, depending on the dose, compared to 6-8% receiving placebo