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We emphasize that the curves in Figure 4 and the numerical values in Table 1 are not precise estimates as they result from very simple calculations (detailed in the Data S1)

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Importantly, both the stalk and ECL1 of GCGR contain several -branched residues that favor the over conformation, in contrast to only one -branched residue (T207) in ECL1 and none in the stalk region in GLP-1R

Holsts laboratory played a central role in characterizing the active intestinal form of GLP-1, demonstrating its therapeutic potential in diabetes, as well as obesity treatment, and developing early drug analogs

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