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2013 Jan;9(1):27-36

Similarly, severe heart failure or pulmonary edema represents a contraindication or strong precaution, as large amounts of glycine solution may expand intravascular volume and precipitate or worsen congestive heart failure or pulmonary congestion

Typically, doses are increased gradually to help reduce side effects and ensure the medication is well-tolerated

Too little tirzepatide and you get no therapeutic benefit

Among people who are overweight or obese, one in three are living with MASH, said Martin Holst Lange, Executive Vice President and Head of Development at Novo Nordisk, who sees a significant unmet medical need in this indication