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Frequently Asked Questions How long until I notice a difference
The SURMOUNT-5 trial, published in The New England Journal of Medicine , directly compared tirzepatide to semaglutide and found tirzepatide produced 47% greater relative weight loss at 72 weeks, 20.2% of body weight versus 13.7%
Our guide on why weight gain occurs on tirzepatide covers the most common reasons and solutions
As a result, Zepbound is being dropped from coverage starting July 1, 2025 , even for patients already using it with good results
If deemed appropriate, Ozempic is incorporated into a comprehensive weight loss plan that includes diet, exercise, and lifestyle changes
