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Most patients tolerate tirzepatide very well, but some may experience nausea, constipation, bloating, or fatigue during the first few weeks
Weight cycling has been linked to lower lean mass and muscle strength, particularly in those who experience multiple cycles (6 times) [13]
In a case-matched study of adjuvant liraglutide following retrieval of the intra-gastric balloon, there was significantly less weight regain in the liraglutide group than the placebo (1.2 kg 0.9, 0.7 1.0, p = 0.010)
And these hormonal shifts are not minor
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