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Whilst the prevalence of both DM and CKD continues to rise globally, effective therapeutic options for DKD have been slow to emerge

This peptide hormone is well known for its mediative effect in regulating cellular glucose transport in the periphery and has been demonstrated to cross the BBB through insulin transporters [128] to act on insulin receptors which are widespread throughout the brain, localized on neurons, astrocytes, and microglia [129,130,131]

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If symptoms persist at the same dose for more than four weeks, contact prescriber

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