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Solubility refers to the dissolution of the drug in an aqueous media, whereas permeability is the ability of a drug to cross membrane barriers and enter into the bloodstream

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Contact your healthcare provider if you experience weight regain of approximately 3-5% of your body weight within a few weeks, return of obesity-related complications such as uncontrolled blood pressure or worsening diabetes control, severe increase in appetite interfering with daily functioning, or psychological distress related to weight changes