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Until the data of the SURPASS-CVOT trial are available, tirzepatide will most likely have a place in the algorithm of T2D therapy for patients with obesity and T2D that have the therapeutic aim to normalize glycemia and decrease body weight

The medication does not directly interact with levothyroxine or interfere with thyroid hormone replacement therapy

While a causal relationship has not been established, patients with depression or other psychiatric conditions should be monitored for changes in mood or behavior, particularly during the initial weeks of treatment or following dose adjustments

For example, estradiol may protect against the development of metabolic syndrome by impacting insulin sensitivity

The incretin mimetics prioritised in the NICE guideline are liraglutide, dulaglutide, injectable and oral semaglutide, and tirzepatide