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Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1

They are a minority in the trial populations, but they exist

Population and endpoints A definitive trial would enroll patients with biopsy-confirmed MASH and clinically meaningful fibrosis typically stage F2F3, the range where progression risk and regulatory interest are highest and would be powered against the two histologic endpoints regulators recognize: resolution of steatohepatitis without worsening of fibrosis, and improvement in fibrosis by at least one stage without worsening of steatohepatitis

Watch for signs including dark urine, dizziness, dry mouth, or decreased urination