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In this regard, GLP-1R agonists (i.e., exenatide) improve insulin resistance suppressing pro-inflammatory phenotypes of monocytes/macrophages, and directly modulating NF-B activation and IL-1, IL-6, and TNF- expression (Yu et al., 2019)

They also strip muscle in a way few weight-loss methods do, and the muscle loss accelerates with rapid titration and a low-protein diet

When GLP-1 medications already require injection management, simplified supplementation reduces decision fatigue and improves compliance

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Furthermore, the Canadian Community Health Survey (CCHS) reported that 30% of adult Canadians were obese in 2022