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Additional factors that may be considered when choosing a medication for you include the medications youve taken previously, if you have concerns about specific side effects such as gastrointestinal, weight changes, sexual or sleep side effects, and if you have any other conditions like bipolar disorder, seizure disorders

doi: 10.1155/2019/2583047 81 CollombatPXuXRavassardPSosa-PinedaBDussaudSBillestrupNet al

In this trial involving adults with obesity, retatrutide demonstrated substantial weight reduction up to approximately 24% of body weight over 48 weeks a magnitude not previously observed with any approved pharmacological agent

What sets retatrutide apart is the dysesthesia side effect, which does not meaningfully occur with the other two medications

Animal studies have shown that ipamorelin is able to bind to primary rat pituitary cells and stimulate the release of GH into the blood