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(1994) with the possible exception of Phe- 12 (substitution to Ala resulted in 133-fold reduced affinity and 13-fold reduced potency), although the larger Tyr side chain in the Xenopus sequence is likely to be a more acceptable substitution compared with Ala
And I think two things around that
Scand J Gastroenterol 2018;53:1429-32.ArticlePubMed 45
Chemistry and Pharmacology of Tinospora Cordifolia
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