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Avg weight loss (72 weeks): ~19.5% (SURMOUNT-1) 15 mg Weeks 21+ Maximum dose

The peptide stacking guide covers compatibility considerations and the peptide stack calculator helps plan multi-compound protocols

However the recent studies suggest the risks may be lower than we first thought

Ligand-independent actions of estrogen receptors (ERs) have also been described, particularly in the uterus, where ER can be activated by growth factor pathways (e.g., IGF-1), leading to receptor recruitment to chromatin in the absence of estrogen binding (Meyer et al., 2011

If you have diabetes risk factors, this needs to be monitored carefully