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Accordingly, acute administration of liraglutide may attenuate intestinal tight junction gene levels via an LPS- and TLR4-dependent mechanism and promote BT under stress conditions, such as those found in the colitis model
Safety Considerations and Adverse Effects While GLP-1 receptor agonists offer numerous benefits, clinicians should be mindful of potential adverse effects

doi: 10.1111/j.1464-5491.2012.03652.x

In future RCTs, key considerations such as the optimal timing of intervention, treatment duration, specific patient subgroups based on molecular diagnosis, and potential systemic adverse events require further investigation
