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The temporal relationship between tirzepatide initiation and symptom onset, followed by normalization of thyroid function after tirzepatide discontinuation, raises the possibility of a drug-related effect

[ 18,19] The microbiome effects include promoting the gut-brain axis for appetite control, while the collagen-supportive aspects also include the stimulation of collagen synthesis

The small sample size of the GLP-1RA, however, limits generalizability, and baseline BMI differences may have influenced the observed outcomes

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TIME : Weekly injection of GLP