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Statistical analysis We did not perform power calculations, but the sample size and animal number for each group were chosen based on study feasibility and prior knowledge of statistical power from previously published experiments

Pitts, PhD, president and co-founder of the Center for Medicine in the Public Interest, former associate commissioner of the FDA and visiting professor at University of Paris School of Medicine, said during the briefing

Best practice in statistics: the use of log transformation

PMID: Summary Keywords biologic therapy, early psoriatic arthritis, GLP-1 receptor agonists, inflammation, metabolic syndrome, psoriasis Citation Ciancio G, Maranini B, Sandri G, Amati G, Bortoluzzi A, Silvagni E, Govoni M and Giuggioli D (2026) Glucagon-like peptide-1 receptor agonists in psoriasis and psoriatic arthritis: emerging evidence and future research opportunities

In terms of its effects, it appears to impact drinking in ways (though not necessarily mechanisms) similar to naltrexone (FDA-approved) and topiramate (prescribed off label for alcohol use disorder), which have a greater effect in reducing intensity of drinking on drinking days relative to their effects on whether someone drinks at all (i.e., abstinent days) although all of them do increase abstinent days to some degree on average)
