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The indirect effects, mediated through reductions in HbA1c and body weight, appeared to explain 45.9% [95% CI 20.771.0%] of the decrease in UACR associated with tirzepatide relative to the pooled comparator and driven primarily by improved glycemic control, with no statistically significant role for weight reduction

Injectable medications, particularly GLP-1 receptor agonists, have become a popular choice because of their proven impact on weight loss

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Acknowledgments This work was funded by the Commonwealth Fund