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UC Davis Health

Another GLP-1/GIP/glucagon receptor triagonist (HM15211) is undergoing preclinical studies for its efficacy in the treatment of T2DM, MASH, and Parkinsons disease

Second-generation long-acting analogs The evolution developed with the emergence of second-generation GLP-1 receptor agonists, suggesting a notable advancement in molecular design and clinical application

Third, the optimal positioning and sequencing of GLP-1-based therapies relative to resmetirom and other emerging MASH agents (e.g., lanifibranor, pegozafermin, semaglutide combination regimens) requires dedicated combination trials, of which preliminary data from the MAESTRO-NASH secondary analysis are encouraging

Days 1-2: Redness and mild swelling gradually fade