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A similar safety profile was observed in the SURMOUNT-2 randomized trial of tirzepatide in adults with obesity and T2DM where GIT adverse events were the most frequently reported with no data on neuro or psychiatric adverse events available [15]
Those who recevied the placebo (no active drug) on average experienced 14% weight regain whilst those who continued on Tirzepatide had a further average weight loss of 5.5%
