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Evolutionary Biology Upon nutrient ingestion enteroendocrine L-cells secrete GLP-1, which has a crucial role in glucose metabolism regulation via enhancing insulin secretion and inhibiting glucagon release

Hypoxia predisposes to structural defects including fibrosis and nephron loss

Mast cell stabilizer (MCAS Connection): GLP-1 receptors are also found on mast cells, and recent studies have shown that GLP-1 RA drugs prevent overactive mast cell degranulation

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