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Severe abdominal pain that does not improve with dietary changes could indicate pancreatitis, a rare but serious side effect

Proteins are vital for muscle growth and repair, and they contribute to feeling full

It is often part of a broader pattern of metabolic dysfunction and is associated with several common health conditions, including: Prediabetes , where blood sugar levels are elevated but not yet in the diabetic range Type 2 diabetes , characterized by chronic insulin resistance and impaired glucose control Polycystic ovary syndrome (PCOS) , where insulin resistance contributes to hormonal imbalance and weight gain Metabolic syndrome , a cluster of risk factors including abdominal obesity, high blood pressure, and abnormal cholesterol Non-alcoholic fatty liver disease (NAFLD) , where excess fat accumulates in the liver due to insulin-driven fat storage Because insulin resistance affects multiple organ systems, addressing it often leads to improvements not only in weight, but also in energy, blood sugar stability, and long-term metabolic health

In this post hoc analysis, 17% to 38% of all women participants shifted to a healthy range for WHtR with tirzepatide compared to 0% to 3% who received placebo