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In 2022, a modified version of the GLP-1/GIP dual agonist, tirzepatide (Zepbound), developed by Eli Lilly induced an average weight loss of 21% in humans with obesity and 15% weight loss in obese patients with diabetes (1)

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Some medications need dose adjustments or withdrawing, especially in the setting of acute illness that can result in dehydration and acute renal failure

Also, because GLP-1 drugs engage the brain's reward circuitry the same system that governs not just craving but everyday motivation prolonged use could, in theory, dampen motivational drive in some people

2 Hims & Hers has been one of the most prominent players in the direct-to-consumer GLP-1 space, yet the company has faced its own headwinds in recent months after being required to pull access to compounded semaglutide following FDA action against mass compounding of GLP-1 drugs