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The complex enteric nervous system within the gut is responsible for intrinsic control, while extrinsic control is driven by the autonomic nervous system, which is responsible for integrating gut function into the complete homeostatic balance of the human organism

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Crit Rev Neurobiol 16:5157 Morris RG, Garrud P, Rawlins JN, OKeefe J (1982) Place navigation impaired in rats with hippocampal lesions

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Consider the following recommendations: Eat your final meal at least 34 hours before bedtime to allow adequate time for digestion Avoid large evening meals , opting instead for smaller, lighter dinners Stay upright for at least 2 hours after eating to facilitate gastric emptying and reduce discomfort Avoid trigger foods that may exacerbate nausea or reflux, particularly in the evening Maintain adequate hydration throughout the day, but reduce fluid intake close to bedtime Sleep hygiene practices remain fundamental for managing sleep disturbances: Maintain a consistent sleep schedule , going to bed and waking at similar times daily Create a relaxing bedtime routine to signal your body that sleep is approaching Ensure your bedroom is cool, dark, and quiet Limit screen time for at least one hour before bed Avoid caffeine after early afternoon and limit alcohol consumption Managing gastrointestinal side effects can significantly improve sleep quality
