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Participants randomized to the 4 mg dose with a 2 mg starting dose had significantly fewer GI adverse events than those started directly at 4 mg

10.1016/S2213-8587(17)30412-6 [DOI] [PubMed] [Google Scholar] 18.Xu D, Nair A, Sigston C, Ho C, Li J, Yang D, et al

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A 300-pound man could see 236 on the scale
