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Merck began trials of the HMG-CoA reductase inhibitor lovastatin in 1980, and won a historic approval in 1987-- showing the medication produced robust reductions in LDL levels

doi: 10.1136/annrheumdis-2020-216924 5 RovinBHParikhSVAlvaradoA

Some newer medications, like tirzepatide, also act on additional metabolic pathways, which may enhance weight-loss results for certain patients

The intensity can range from mildly noticeable to genuinely overwhelming, depending on how much gas has accumulated, what you ate recently, and how effectively your digestive tract is moving food along

Nat Rev Gastroenterol Hepatol 2018;15:11-20