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Currently, there is an ongoing randomised double-masked placebo-controlled trial, the SUMMIT trial, studying the efficacy and safety of tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide and GLP-1 receptors, versus placebo in HFpEF patients with obesity (NCT04847557)

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In an analysis of more than 100 clinical trials of earlier anti-obesity medications, in studies lasting up to 76 weeks, drug-induced weight loss never exceeded more than nine pounds (4 kg)

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