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Their effects on the individual components of MACE, myocardial infarction (reduced in LEADER and Harmony Outcomes), and stroke (reduced in SUSTAIN-6 and REWIND), varied in each trial (Table 1)

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Some patients find that evening dosing helps manage daytime nausea, whilst others prefer morning administration to monitor symptoms throughout the day

GLP-1 receptor signaling differentially modifies the outcomes of sterile vs viral pulmonary inflammation in male mice