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These mutations cause the early onset of severe obesity and an insatiable appetite (hyperphagia), meaning that the genetic component may account for 4070% of obesity
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doi: 10.1210/jc.2009-1719
GHSR activates a G q/11 -coupled GPCR in the pituitary to stimulate intracellular calcium mobilization from the endoplasmic reticulum 33 , whereas in NG neurons, Grabauskas et al
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