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People with an eGFR below 30, meaning stage 4 or 5 chronic kidney disease, should approach retatrutide with serious caution

Retatrutide will likely slot in as a second-line option for patients who plateau on tirzepatide or require maximal weight loss for surgical candidacy or metabolic disease reversalonce Phase 3 data clarifies its cardiovascular safety profile

Under the brand name Wegovy, it is used for chronic weight management, alongside a reduced calorie diet and regular exercise, in patients with a BMI of 30 or higher

For some patients, microdosing GLP-1 can support consistent, sustainable weight lossespecially when combined with nutrition and lifestyle changes

Compounded versions may not meet the standards that brand names have met