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Thats why GLP-1s show up in clinical trials for cardiovascular disease, kidney disease, heart failure, dementia, NASH (fatty liver), and cancer

The baseline health status of participants varies significantly across studies

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Neurogastroenterol Motil 2010;22:664-e203.ArticlePubMed 26

13 Similarly, treatment with semaglutide 2.4 mg once weekly for one year in adults with prediabetes and obesity resulted in reversion to normoglycaemia in 81% compared with 14% on placebo