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16 Based on these data, it is reasonable to decrease background prandial insulin doses by 50%, or even hold the prandial insulin altogether in patients with good glucose control or a history of hypoglycemia when starting a GLP-1 RA

Subsequent studies revealed that co-infusion of GLP-1 with GCG can mitigate the GCG-induced hyperglycaemia [34], while preserving GCGs metabolic benefits, providing a strong rationale for the development of GLP1/GCG co-agonists as obesity treatments (Fig

Gradual weight loss is ideal to maintain enough fat for grafting if needed

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