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doi: 10.1016/j.bbrc.2009.10.054 41 Portela-GomesGMHoogA

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In a pivotal trial, participants taking Wegovy lost an average of 15% of their body weight over 68 weeks

Clinical Case: In a Phase II clinical trial, the combination therapy group showed a 40% higher improvement rate in depressive symptoms, a 20% reduction in cortisol levels compared to monotherapy, and more significant HPA axis functional recovery

Both FDA and EMA offer an orphan designation for drugs that are targeted at rare diseases