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Comparative metabolic and hepatic effects of GLP-1-based mono-, dual-, and triple-agonist therapies GLP-1 receptor signaling Intestinal L-cells serve as the primary source of GLP-1 synthesis, which operates via G-protein coupled receptors present in pancreatic beta cells, gastrointestinal and central neural systems, cardiac tissues, and kidneys [26]

A recent umbrella review encompassing data from 108,030 men with diabetes estimated a global pooled prevalence of 65.8% [10]

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While these medications can aid in initial weight loss, long-term success often depends on sustained behavioural changes, such as diet and exercise modifications

In contrast, asymptomatic patients without risk factors generally do not require pre-treatment screening