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In a two-year extension limited to people with a BMI of 35 or higher, average weight loss reached 30.3% at 104 weeks

doi: 10.1136/bmjdrc-2021-002517 [DOI] [PMC free article] [PubMed] [Google Scholar] 40.Durden E, Liang M, Fowler R, Panton UH, Mocevic E

Adherence to dietary modifications and physical activity recommendations enhances weight loss and metabolic improvements

Firstly, it improves glycemic control by reducing HbA1c levels, thus mitigating the vascular damage caused by hyperglycemia

doi: 10.1016/j.peptides.2019.170230
