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July 2024

PPAR2 is primarily expressed in adipose tissue and promotes the differentiation and proliferation of adipocytes, which are derived from fibroblasts, resulting in an increase in adiposity [26]

Beneficial Cardiometabolic Effects: They do not reduce CVD risk per se but are likely to contribute to favorable lipid profiles, lower blood pressure, and reduced inflammation, consequently potentially supporting heart health indirectly

Given the promising research in organ fibrosis and the reduction in chronic low-grade inflammation and joint fibrosis in arthritis [1], I think this is likely, but research is needed

Vitam Horm 84: 81-110, 2010
