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Clinicians should assess each patients needs individually when deciding whether to prescribe GLP-1 receptor agonists, but based on our findings, there is no indication that the treatment poses an increased risk of suicidality in adolescents with obesity. Kerem said the findings reveal the need for future studies to examine the impact of GLP-1 receptor agonist on psychiatric measures

That three-receptor approach is what separates it from Tirzepatide (dual agonist) and Semaglutide (single agonist), and the clinical data reflects that gap clearly