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[DOI] [PMC free article] [PubMed] [Google Scholar] 189.Fan H., Gong N., Li T.F., Ma A.N., Wu X.Y., Wang M.W

Drug Interaction Studies JANUMET XR Coadministration of multiple doses of sitagliptin (50 mg) and metformin HCl (1000 mg) given twice daily did not meaningfully alter the pharmacokinetics of either sitagliptin or metformin in patients with type 2 diabetes

Its very stressful for patients who have been doing really well, who are having good tolerance and feel like they have hit their stride in terms of medication, nutrition and exercise