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Harvard geneticist David Sinclair reveals a rare but serious blindness risk linked to GLP-1 drugs, estimating 20,00030,000 NAION cases per year in

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GLP-1 RAs provide sustained central and peripheral GLP-1R activation that blunts appetite via hypothalamusvagusNTS circuits, improves metabolic health, and may reduce alcohol and other substance-related craving and reward signals.

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