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N Engl J Med 346:393403 Bailey CJ, Turner RC (1996) Metformin

The GLP-1 Legacy is a book that focuses specifically on this phase, with a foreword by Professor Jane Ogden

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Clinical signals that may prompt evaluation of overbasalization include basal dose more than 0.5 IU/kg, high bedtime-morning or post-preprandial glucose differential, hypoglycemia (aware or unaware), and high variability

Research Evidence Comparison# Retatrutide Research# Phase 1 : First-in-human study established safety and pharmacokinetics Phase 2 (n=338) : Published in NEJM (2023), demonstrated dose-dependent weight loss up to 24.2% at 48 weeks with 12 mg dose