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Preclinical models, clinical trials and real-world observational studies strongly support the hypothesis that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and SGLT2 inhibitors may confer neuroprotective benefits

Access up-to-date information on glucoregulatory hormones and GLP-1/GIP receptor agonists with clinical guidance at Healio.

Other notable greenlights this year include Bristol Myers Squibbs Cobenfy, the first novel therapeutic for schizophrenia in 35 years, and Madrigal Pharmaceuticals Rezdiffra, the first-ever treatment for MASH.

ANALYSIS METHODOLOGY For a deeper understanding of where off-label GLP-1 uses are emerging, Storyful Intelligence analyzed 29.9k mentions across conversations on X, Facebook, Reddit, and Instagram, from February 1, 2024, to March 24, 2025

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