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The best results come from pairing the medicine with food, activity, sleep, and stress routines you can keep

For other potential indications such as substance use disorders or depression, more randomized controlled trials in humans are still needed

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Their effectiveness depends not just on affordability, but on sustained, guided use as part of a broader strategy that includes diet, lifestyle and regular medical care.

doi: 10.1016/S0016-5085(97)70080-5
