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Gastrointestinal autoimmune conditions Patients with celiac disease, Crohn's disease, ulcerative colitis, or autoimmune hepatitis face particular challenges with tirzepatide

Patients with contraindications to GLP-1 agonists, including personal or family history of medullary thyroid carcinoma, history of pancreatitis, severe gastroparesis, or pregnancy, should not use either mazdutide or tirzepatide

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Regarding urinary tract infections (UTIs) , clinical trials and post-marketing surveillance data show no established causal link between Rybelsus and increased UTI risk